氏名
降旗謙一（ふりはた けんいち）M.D., Ph.D.
勤務先
SRL理事
医療法人社団慶幸会理事長
同ピーワンクリニック院長
教育
| 1978 | M.D. | 慶應義塾大学医学部 |
| 1978.5.31 | 第65回医師国家試験合格（医籍登録 第241,063号） | |
| 1985 | Ph.D. | 慶應義塾大学医学部 |
職歴
| 1978-80 | 慶應義塾大学医学部付属病院内科研修医 |
| 1980-82 | 内科勤務医、永寿総合病院、東京都台東区 |
| 1982-85 | 慶應義塾大学医学部専修医、内科血液学 |
| 1985-88 | Postdoctoral Research Fellow, Immunochemistry Laboratory, The Blood Center of Southeasthern Wisconsin, Milwaukee, WI, USA |
| 1988-93 | 内科医員(血液班)、信州大学医学部付属病院第二内科、長野県松本市 |
| 1993.5 | 講師、信州大学医学部臨床検査医学 |
| 1993.9-99.1 | 助教授、信州大学医学部臨床検査医学、および副部長、信州大学医学部付属病院 中央検査部 |
| 1998-99.3 | Visiting Scientist, The Scripps Research Institute, La Jolla, CA, USA |
| 1999.4-02.1 | Senior Research Associate, The Scripps Research Institute, La Jolla, CA. USA |
| 2002.2-2003.10 | Senior Research Scientist, Torrey Pines Institute for Molecular Studies, San Diego, CA. USA |
| 2003.11-現在 | （株）SRL理事 |
| 2005.6-07.2 | ピーワンクリニック院長 |
| 2007.3-現在 | 医療法人社団慶幸会理事長、ピーワンクリニック院長 |
略歴（総括）
1978年(昭和53年)春に慶應義塾大学医学部を卒業し、国家試験に合格後、同付属病院で2年間の 内科研修を終了。
教育の一環として台東区の永寿総合病院内科に2年間常勤医師として勤務し、主として血液疾患の患者の診療に当たる。
1982年夏に慶應義塾大学医学部内科に戻り、血液研究室に所属する。
血小板の免疫の研究に従事し、1985年1月に博士号(医学博士)を取得。同年2月より米国ウィスコンシン州ミルウォーキー市にあるThe Blood Center of Southeastern Wisconsinで、Dr. Kunickiの元で引き続き血小板の免疫の研究に従事した。
1988年3月に帰国し、同年4月から信州大学医学部第二内科に勤務。
その後輸血部勤務を経て臨床検査医学に移り、 1993年5月より講師(中央検査部副部長)、同年9月より助教授となった。
その後全国の国立大学病院で初の遺伝子診療部の立ち上げに参画し、1998年2月に開催された長野冬季オリンピックではドーピングコントロール責任者を務めた。
同年6月より米国カリフォルニア州サンディエゴにあるThe Scripps Research InstituteでVisiting Scientistとして血小板を中心とした血栓に関する分子生物学的研究に従事。
その後ビザの関係から近隣のTorrey Pines Institute for Molecular Studiesに移籍。
2003年9月にグリーンカードを取得後、翌10月に帰国し、同11月より我が国最大の臨床検査センターである(株)エスアールエルの理事に就任。
主として新しい検査法の発掘、開発の指導に当たる。
その傍ら、2005年6月より治験専門のピーワンクリニックを開設して院長となり、現在に至る。
また2007年2月より医療法人社団慶幸会を設立し、理事長となり現在に至る。
今までの経歴を通して臨床医（血液内科）としての経験、基礎研究者（免疫学、分子生物学、細胞培養など）としての実績、大学病院の臨床検査部(遺伝子検査を含む)の運営、遺伝子診療部(信州大学)の立ち上げおよび診療への参画、日本最大の臨床検査センターの理事としての視点および人脈、治験クリニックの経営を通じた創薬への関与、米国での生活（合計8年半）による国際的感覚などを身に着けた。
その他
| 1995-present | 評議員、日本検査医学会(血液学) |
| 1996-98 | Director, Doping Control, 長野冬季オリンピック大会 |
所属学会
日本内科学会、日本臨床検査医学会、日本検査血液学会、日本臨床薬理学会など
American Society of Hematology; International Society of Thrombosis and Haemostasis
英語論文
| 01. | Ikeda Y, Furihata K, Imai M, Sugiura K, Toyama K, Yamamoto M, Watanabe K, Ando Y: [Effect of anti-platelet tubulin antibody on platelet functions (author’s transl)]. Nippon Ketsueki Gakkai Zasshi 44:652, 1981 |
|---|---|
| 02. | Kunicki TJ, Furihata K, Bull B, Nugent DJ: The immunogenicity of platelet membrane glycoproteins. Transfus Med Rev 1:21, 1987 |
| 03. | Furihata K, Nugent DJ, Bissonette A, Aster RH, Kunicki TJ: On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa. Evidence for heterogeneity of glycoprotein IIIa. J Clin Invest 80:1624, 1987 |
| 04. | Furihata K, Hunter J, Aster RH, Koewing GR, Shulman NP, Kunicki TJ: Human anti-PlE1 antibody recognizes epitopes associated with the alpha subunit of platelet glycoprotein Ib. Br J Haematol 68:103, 1988 |
| 05. | Kickler TS, Herman JH, Furihata K, Kunicki TJ, Aster RH: Identification of Bakb, a new platelet-specific antigen associated with posttransfusion purpura. Blood 71:894, 1988 |
| 06. | Kunicki TJ, Furihata K, Nugent D: Glycoprotein IIb-IIIa as an immunologic target. Curr Stud Hematol Blood Transfus :44, 1988 |
| 07. | Simon TL, Collins J, Kunicki TJ, Furihata K, Smith KJ, Aster RH: Posttransfusion purpura associated with alloantibody specific for the platelet antigen, Pen(a). Am J Hematol 29:38, 1988 |
| 08. | Ishida F, Saitoh H, Furihata K, Furuta S, Sonoyama M, Oshimi K: [Granular lymphocyte leukemia of natural killer cell type; association with 47 XY, +8 by interleukin 2 (IL-2)-stimulated chromosomal analysis]. Rinsho Ketsueki 31:1711, 1990 |
| 09. | Kunicki TJ, Furihata K, Kekomaki R, Scott JP, Nugent DJ: A human monoclonal autoantibody specific for human platelet glycoprotein IIb (integrin alpha IIb) heavy chain. Hum Antibodies Hybridomas 1:83, 1990 |
| 10. | Ishida F, Saji H, Maruya E, Furihata K: Human platelet-specific antigen, Siba, is associated with the molecular weight polymorphism of glycoprotein Ib alpha. Blood 78:1722, 1991 |
| 11. | Murata M, Furihata K, Ishida F, Russell SR, Ware J, Ruggeri ZM: Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness. Blood 79:3086, 1992 |
| 12. | Wang R, Furihata K, McFarland JG, Friedman K, Aster RH, Newman PJ: An amino acid polymorphism within the RGD binding domain of platelet membrane glycoprotein IIIa is responsible for the formation of the Pena/Penb alloantigen system. J Clin Invest 90:2038, 1992 |
| 13. | Tozuka M, Hidaka H, Miyachi M, Furihata K, Katsuyama T, Kanai M: Identification and characterization of apolipoprotein(AII-E2-AII) complex in human plasma lipoprotein. Biochim Biophys Acta 1165:61, 1992 |
| 14. | Ogasawara K, Ueki J, Takenaka M, Furihata K: Study on the expression of ABH antigens on platelets. Blood 82:993, 1993 |
| 15. | Ota H, Nakayama J, Fujimori Y, Furihata K, Katsuyama T, Moriyama S, Hata S, Ono K. Organized Differentiation of Tumor –Cells of Villous Adenomas of The Large- Intesitine. Acta Histochemica et Cytochemica 26:117, 1993 |
| 16. | Yamamoto K, Hsu SP, Yoshida K, Ikeda S, Nakazato M, Shiomi K, Cheng SY, Furihata K, Ueno I, Yanagisawa N: Familial amyloid polyneuropathy in Taiwan: identification of transthyretin variant (Leu55–>Pro). Muscle Nerve 17:637, 1994/li> |
| 17. | Kawakami Y, Ueno I, Katsuyama T, Furihata K, Matsumoto H: Restriction fragment length polymorphism (RFLP) of genomic DNA of Moraxella (Branhamella) catarrhalis isolates in a hospital. Microbiol Immunol 38:891, 1994 |
| 18. | Kawakami Y, Furuwatari C, Akahane T, Okimura Y, Furihata K, Katsuyama T, Matsumoto H: In vitro activity of arbekacin against clinical isolates of methicillin- resistant Staphylococcus aureus in a hospital. J Antibiot (Tokyo) 47:507, 1994 |
| 19. | Yoshida K, Furihata K, Takeda S, Nakamura A, Yamamoto K, Morita H, Hiyamuta S, Ikeda S, Shimizu N, Yanagisawa N: A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat Genet 9:267, 1995 |
| 20. | Ishida F, Furihata K, Ishida K, Yan J, Kitano K, Kiyosawa K, Furuta S: The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145. Blood 86:1356, 1995 |
| 21. | Ota H, Katsuyama T, Akamatsu T, Fujimori Y, Matsuzawa K, Ishii K, Honda T, Nakayama J, Furihata K, Ono K, Maeda K. Application of Mucin Histochemistry for Pathological Diagnosis – Expression of Gastric Phenotypes in Metaplastic and Neoplastic Lesions and Its Relation to The Organoid Differentiation. Acta Histochemica et Cytochemica 28:43, 1995 |
| 22. | Ishida F, Furihata K, Ishida K, Kodaira H, Han KS, Liu DZ, Kitano K, Kiyosawa K: The largest isoform of platelet membrane glycoprotein Ib alpha is commonly distributed in eastern Asian populations. Thromb Haemost 76:245, 1996 |
| 23. | Ikeda S, Yanagisawa N, Hanyu N, Furihata K, Kobayashi T: Coexistence of type I familial amyloid polyneuropathy and spinocerebellar ataxia type 1. Clinical and genetic studies of a Japanese family [letter]. J Neurol Neurosurg Psychiatry 60:586, 1996 |
| 24. | Tozuka M, Ohta H, Hidaka H, Okumura N, Furihata K, Katsuyama T: Influence of apolipoprotein E phenotypes on total serum cholesterol in Japanese children. Clin Chim Acta 247:175, 1996 |
| 25. | Tozuka M, Hidaka H, Okumura N, Ichikawa T, Furihata K, Katsuyama T: A case of immunoglobulin A-lambda conjugated with lactate dehydrogenase- 5 isoenzyme, causing an extremely high enzyme activity in serum. Clin Chem 42:1288, 1996 |
| 26. | Kawa S, Yoshizawa K, Tokoo M, Imai H, Oguchi H, Kiyosawa K, Homma T, Nikaido T, Furihata K: Inhibitory effect of 220-oxa-1,25-dihydroxyvitamin D3 on the proliferation of pancreatic cancer cell lines. Gastroenterology 110:1605, 1996 |
| 27. | Sakurai A, Katai M, Furihata K, Hashizume K: Gs alpha mutation may be uncommon in patients with multiple endocrine neoplasia type 1. J Clin Endocrinol Metab 81:2394, 1996 |
| 28. | Okumura N, Furihata K, Terasawa F, Nakagoshi R, Ueno I, Katsuyama T: Fibrinogen Matsumoto I: a gamma 364 Asp–>His (GAT–>CAT) substitution associated with defective fibrin polymerization. Thromb Haemost 75:887, 1996 |
| 29. | Okumura N, Furihata K, Terasawa F, Ishikawa S, Ueno I, Katsuyama T: Fibrinogen Matsumoto II: gamma 308 Asn–>Lys (AAT–>AAG) mutation associated with bleeding tendency. Br J Haematol 94:526, 1996 |
| 30. | Kawa S, Nikaido T, Aoki Y, Zhai Y, Kumagaya T, Furihata K, Fujii S, Kiyosawa K: Arotinoid mofarotene (RO40-8757) up-regulates p21 and p27 during growth inhibition of pancreatic cancer cell lines. Int J Cancer 72:906, 1997 |
| 31. | Kawakami M, Okaneya T, Furihata K, Nishizawa O, Katsuyama T: Detection of prostate cancer cells circulating in peripheral blood by reverse transcription-PCR for hKLK2. Cancer Res 57:4167, 1997 |
| 32. | Kobayashi H, Takemura Y, Miyachi H, Kawabata M, Mori S, Kawai Y, Furihata K, Sekiguchi S, Watanabe K: Quantitative analysis of human multidrug resistance 1 (MDR1) gene expression by nonisotopic competitive reverse transcriptase polymerase chain reaction assay. J Clin Lab Anal 11:258, 1997 |
| 33. | Kawa S, Nikaido T, Aoki Y, Zhai Y, Kumagai T, Furihata K, Fujii S, Kiyosawa K: Vitamin D analogues up-regulate p21 and p27 during growth inhibition of pancreatic cancer cell lines. Br J Cancer 76:884, 1997 |
| 34. | Ichijo T, Matsumoto A, Kobayashi M, Furihata K, Tanaka E: Quantitative measurement of HCV RNA in the serum: a comparison of three assays based on different principles [published erratum appears in J Gastroenterol Hepatol 1998 May;13(5):following 550]. J Gastroenterol Hepatol 12:500, 1997 |
| 35. | Furuya N, Kawa S, Akamatsu T, Furihata K: Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice. Gastroenterology 113:593, 1997 |
| 36. | Kodaira H, Ishida F, Shimodaira S, Takamiya O, Furihata K, Kitano K: Resistance to activated protein C and Arg 506 Gln factor V mutation are uncommon in eastern Asian populations. Acta Haematol 98:22, 1997 |
| 37. | Ota M, Katsuyama Y, Mizuki N, Ando H, Furihata K, Ono S, Pivetti-Pezzi P, Tabbara KF, Palimeris GD, Nikbin B, Davatchi F, Chams H, Geng Z, Bahram S, Inoko H: Trinucleotide repeat polymorphism within exon 5 of the MICA gene (MHC class I chain-related gene A): allele frequency data in the nine population groups Japanese, Northern Han, Hui, Uygur, Kazakhstan, Iranian, Saudi Arabian, Greek and Italian. Tissue Antigens 49:448, 1997 |
| 38. | Nimura Y, Furuwatari C, Fujimori M, FUrimori Y, Nakata S, Ito K, Hama Y, Shingu K, Adachi W, Ogiso Y, Furihata K, Katsuyama T, Amano J. Germline mutations of the APC gene in two Japanese adenomatous polyposis patients. Jpn J Hum Genet. 42(3):433-9, 1997 |
| 39. | Kumagai T, Malaty HM, Graham DY, Hosogaya S, Misawa K, Furihata K, Ota H, Sei C, Tanaka E, Akamatsu T, Shimizu T, Kiyosawa K, Katsuyama T: Acquisition versus loss of Helicobacter pylori infection in Japan: results from an 8-year birth cohort study. J Infect Dis 178:717, 1998 |
| 40. | Misawa K, Kumagai T, Shimizu T, Furihata K, Ota H, Akamatsu T, Katsuyama T: A new histological procedure for re-evaluation of the serological test for Helicobacter pylori. Eur J Clin Microbiol Infect Dis 17:14, 1998 |
| 41. | Aoyama T, Peters JM, Iritani N, Nakajima T, Furihata K, Hashimoto T, Gonzalez FJ: Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 273:5678, 1998 |
| 42. | Sato Y, Sakurai A, Miyamoto T, Hiramatsu K, Katai M, Furihata K, Hashizume K: Hyperfunctioning thyroid adenoma concomitant with papillary thyroid carcinoma, follicular thyroid adenoma and primary hyperparathyroidism. Endocr J 45:61, 1998 |
| 43. | Kubota T, Sakurai A, Arakawa K, Shimazu M, Wakui K, Furihata K, Fukushima Y: Identification of two novel mutations in the OCRL1 gene in Japanese families with Lowe syndrome. Clin Genet 54:199, 1998 |
| 44. | Karasawa Y, Kobayashi M, Nakano Y, Aoki Y, Kawa S, Kiyosawa K, Seki H, Kawasaki S, Furihata K, Itoh N: A case of glycogen storage disease type Ia with multiple hepatic adenomas and G727T mutation in the glucose-6-phosphatase gene, and a comparison with other mutations previously reported. Am J Gastroenterol 93:1550, 1998 |
| 45. | Higuchi Y, Furihata K, Ueno I, Ishikawa S, Okumura N, Tozuka M, Sakurai N: Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R. Br J Haematol 103:867, 1998 |
| 46. | Furuwatari C, Yagi A, Yamagami O, Ishikawa M, Hidaka E, Ueno I, Furihata K, Ogiso Y, Katsuyama T: A comprehensive system to explore p53 mutations. Am J Clin Pathol 110:368, 1998 |
| 47. | Yazaki M, Yoshida K, Nakamura A, Furihata K, Yonekawa M, Okabe T, Yamashita N, Ohta M, Ikeda S: A novel splicing mutation in the ceruloplasmin gene responsible for hereditary ceruloplasmin deficiency with hemosiderosis. J Neurol Sci 156:30, 1998 |
| 48. | Furihata K, Drousiotou A, Hara Y, Christopoulos G, Stylianidou G, Anastasiadou V, Ueno I, Ioannou P: Novel splice site mutation at IVS8 nt 5 of HEXB responsible for a Greek- Cypriot case of Sandhoff disease. Hum Mutat 13:38, 1999 |
| 49. | N. Hanaoka, K. Yoshida, A. Nakamura, K. Furihata, T. Seo, Y. Tani, J. Takahashi, S. Ikeda and N. Hanyu. A novel frameshift mutation in the McLeod syndrome gene in a Japanese family. J Neurol Sci, 165:6-9, 1999 |
| 50. | Drousiotou A, Stylianidou G, Anastasiadou V, Christopoulos G, Mavrikiou E, Georgiou T, Kalakoutis G, Oladimeji A, Hara Y, Suzuki K, Furihata K, Ueno I, Ioannou PA, Fensom AH. Sandhoff disease in Cyprus: population screening by biochemical and DNA analysis indicates a high frequency of carriers in the Maronite community. Hum Genet.107: 12-7, 2000 |
| 51. | Kobayashi H, Takemura Y, Kawai Y, Miyachi H, Kawabata M, Matsumura T, Yamashita T, Mori S, Furihata K, Shimodaira S, Motoyoshi K, Hotta T, Sekiguchi S, Ando Y, Watanabe K. Competitive reverse transcription-polymerase chain reaction assay for quantification of human multidrug resistance 1 (MDR1) gene expression in fresh leukemic cells. J Lab Clin Med. 135:199-209, 2000 |
| 52. | Miyabayashi H, Furihata K, Shimizu T, Ueno I, Akamatsu T. Influence of oral Helicobacter pylori on the success of eradication therapy against gastric Helicobacter pylori. Helicobacter 5: 30-7, 2000 |
| 53. | Furihata K, Clemetson KJ, Deguchi H, Kucniki TJ. Variation in Human Platelet Glycoprotein VI Content Modulates Glycoprotein VI–Specific Prothrombinase Activity. Arterioscler Thromb Vasc Biol 21: 1857-1863, 2001 |
| 54. | Furihata K, Nugent DF, Kunicki TJ. Influence of Platelet Collagen Receptor Polymorphisms on Risk for Arterial Thrombosis. Archives of Pathology & Laboratory Medicine 126: 305–309, 2002 |
| 55. | Furihata K, Kunicki TJ. Characterization of Human Glycoprotein VI Gene 5’ Regulatory and Promoter Regions. Arterioscler Thromb Vasc Biol 22: 1733-1739, 2002 |
| 56. | OkanoA, Usuda N, Furihata K, Nakayama K, Bao Tin Q, Okamoto T, Suzuki T. Huntingtin-interacting protein-1-related protein of rat (rHIP1R) is localized in the postsynaptic regions. Brain Res. 967(1-2):210-25, 2003 |
| 57. | Kato K, Kanaji T, Russell S, Kunicki TJ, Furihata K, Kanaji S, Marchese P, Reininger A, Ruggeri ZM, and Ware J. The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion. Blood 2003 Sep 1;102(5):1701-7. |
| 58. | Kanaji S, Kanaji T, Furihata K, Ware J, and Kunicki TJ. Convulxin binds to native, human glycoprotein Ib alpha. J Biol Chem. 2003 Oct 10;278(41):39452-60. Epub 2003 Jul 24. |
| 59. | Kunicki TJ, Cheli Y, Moroi M, Furihata K. The influence of N-linked glycosylation on the function of platelet glycoprotein VI. Blood. 2005 Oct 15;106(8):2744-9. Epub 2005 Jul 12. |
| 60. | Kato K, Furihata K, Cheli Y, Radis-Baptista G, Kunicki TJ.Effect of multimer size and a natural dimorphism on the binding of convulxin to platelet glycoprotein (GP)VI. J Thromb Haemost. 2006 May;4(5):1107-13. |
臨床薬理関係
- 渡辺義人ほか、臨床試験における臨床検査値異常の判定基準案―基準変化値を指標とした 方法の提案―、臨床薬理38（2）:81-88、2007
- 降旗謙一ほか、アムロジピンOD錠 2.5mg 「トーワ」およびアムロジピンOD錠 5mg 「トー ワ」の健康成人における生物学的同等性、医学と薬学59（5）：787-806、2008
- 降旗謙一ほか、ビカルタミド錠80ｍｇ「NK」の健康成人男性における生物学的同等性試験、 医学と薬学61(2)：189-195、2009
